Feasibility and Safety of Continuous and Chronic Bilateral Deep Brain Stimulation of the Medial Forebrain Bundle in the Naïve Sprague-Dawley Rat

Table 1

Semiquantitative analysis of region specific early gene c-fos expression across the experimental animals.

Animal	Group	Prelimbic cortex	Nucleus accumbens shell	Somatosensory cortex	Dorsomedial thalamic nuclei	Dorsolateral striatum
1	Control	+	−	−	+	−
6	Control	+	−	+	+	−
9	Control^*	++	++	++	++	−
13	Control^*	+++	++	+++	+++	++
2	DBS A	++	++	+	++	+
4	DBS A	+	++	−	++	−
8	DBS A^*	++	+	++	++	−
10	DBS A	++	+++	+++	++	−
3	DBS B	+	+	+	+	−
12	DBS B	+++	+++	+++	++	+
15	DBS B^*	++	++	+	++	+
20	DBS B^*	++	++	−	++	−
7	DBS C	+	+	+	+	−
11	DBS C	+++	+++	++	+++	−
17	DBS C	+++	+++	+++	+++	+
18	DBS C^*	+++	+++	++	+++	−

– no expression; + mild; ++ moderate; +++ high expression; asterisks indicate a subgroup of animals stimulated for 2 hours preceding perfusion.