Sex Differences in Neuropsychiatric Symptoms of Alzheimer’s Disease: The Modifying Effect of Apolipoprotein E ε4 Status

Table 1

Characteristics of subjects and ApoE genotype frequencies.

	Mild AD			Moderate to severe AD
	Male	Female	value	Male	Female	value
	()	()		()	()
Age	71.0 (9.1)	70.9 (10.0)	0.967	69.0 (10.1)	66.7 (10.6)	0.156
Education (yr)	9.2 (4.6)	6.4 (5.4)	0.001	8.0 (4.6)	4.8 (4.4)	<0.001
MMSE	17.9 (5.6)	17.1 (4.9)	0.294	12.8 (6.0)	12.0 (5.1)	0.803
ApoE genotype
ε4 negative	56 (75.7)	46 (54.8)	0.006	40 (61.5)	55 (59.8)	0.825
ε2/ε3	7 (9.5)	9 (10.7)	0.794	6 (9.2)	5 (9.1)	0.365
ε3/ε3	49 (66.2)	37 (44.0)	0.005	34 (52.3)	50 (54.3)	0.801
ε4 positive	18 (24.3)	38 (45.2)	0.006	25 (38.5)	37 (40.2)	0.825
ε2/ε4	0	1 (1)	1.000	1 (1.5)	2 (2.2)	1.000
ε3/ε4	14 (18.9)	34 (40.5)	0.003	19 (29.2)	30 (32.6)	0.653
ε4/ε4	4 (5.4)	3 (3.6)	0.707	5 (7.7)	5 (5.4)	0.742

Values are presented as numbers (percentages).