Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study

Table 2

Study structure timing.

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(T-2) = screening part I

     Clinical and demographic data

     MoCA test¹, CDR², and GDS-15³

     HAMD-17⁴ and HAMA-14⁵

     Signed informed-consent forms

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(T-1) = screening part II

   IQCODE⁶ and B-ADL⁷

   Lab blood sample analysis

   Brain MRI/Hachinsky Ischemic Score

   SCID DSM-IV⁸

   Randomization

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(T0) = 1st cognitive assessment battery (baseline)

    1st rTMS session

    Collateral effects scale

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(T1) = 10th rTMS session

   2nd cognitive assessment batery

   Collateral effects scale

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(T2) = one month after T1

       3rd cognitive assessment battery

       IQCODE and B-ADL

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MoCA test: Montreal Cognitive Assessment test; ²CDR: Clinical Dementia Rating; ³GDS-15: 15-Item Geriatric Dementia Scale; ⁴HAMD-17: 17-Item Hamilton Depression Scale; ⁵HAMA-14: 14-item Hamilton Anxiety Scale; ⁶IQCODE: Informant Questionnaire on Cognitive Decline in the Elderly; ⁷B-ADL: Bayer Activities of Daily Living Scale; ⁸SCID-DSM-IV: Structured Clinical Interview for DSM-IV Axis I Disorders-Diagnostic and Statistical Manual of Mental Disorders, fourth edition. Cognitive assessment battery: MMSE: Minimental State Examination; RBMT: Rivermead Behavioral Memory Test; WMS: Wechsler Memory Scale; WAIS: Wechsler Adult Intelligence Scale; RAVLT: Rey Auditory-Verbal Learning Test; Stroop: Stroop Color-Word Interference Test; Trail Making Test A/B.