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Behavioural Neurology
Volume 2015, Article ID 294127, 8 pages
Research Article

Gender Differences in the Behavioral Symptom Severity of Prader-Willi Syndrome

1Department of Psychiatry, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama 343-8555, Japan
2Ikezawa Hospital, 551 Shimo-Shingo, Hanyu, Saitama 348-0046, Japan
3Department of Psychiatry, Dokkyo Medical University School of Medicine, 880 Kita-Kobayashi, Mibu-Machi, Shimotuka-Gun, Tochigi 321-0293, Japan
4Department of Pediatrics, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama 343-8555, Japan
5Nakagawanosato Ryoiku Center, 222 Shimo-Akaiwa, Matsubushi-Machi, Kita-Katsushika-Gun, Saitama 343-0116, Japan

Received 30 July 2015; Accepted 20 October 2015

Academic Editor: Hrayr Attarian

Copyright © 2015 Masao Gito et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. This study measured gender differences in Prader-Willi syndrome (PWS) in regard to the severity of behavioral symptoms. Methods. The Food Related Problem Questionnaire (FRPQ), the Aberrant Behavior Checklist Japanese Version, the Childhood Routines Inventory, the Pervasive Developmental Disorders Autism Society Japan Rating Scale, and Japanese ADHD-RS were administered to PWS patients (45 males aged 6 to 58 and 37 females aged 6 to 45). To examine the effects that gender and genotype have on the severity of each symptom, two-way ANOVAs were conducted. Results. Significant interactions were found only in regard to FRPQ scores, such as FRPQ total score ( = 8.43, ). The FRPQ of male deletion (DEL) individuals was higher than that of female DEL and male mUPD. The FRPQ of male maternal uniparental disomy (mUPD) was lower than that of female mUPD. Conclusions. In terms of problem behaviors, routines, autistic behaviors, and hyperactivity, no significant differences were found. Food-related behaviors in DEL were more severe in males, although those in mUPD were less severe in males.