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Behavioural Neurology
Volume 2015, Article ID 963460, 14 pages
http://dx.doi.org/10.1155/2015/963460
Research Article

Different Temporal Patterns of Specific and General Autobiographical Memories across the Lifespan in Alzheimer’s Disease

1Service of Neurology and CMRR, Neuropsychology Unit, University Hospital of Strasbourg, 1 avenue Molière, 67000 Strasbourg, France
2INSERM, Cognitive Neuropsychology and Pathophysiology of Schizophrenia (U1114), University of Strasbourg, 1 place de l’Hôpital, 12 rue Goethe, 67000 Strasbourg, France
3CNRS, ICube Laboratory (UMR 7357), University of Strasbourg, Pôle API, boulevard S. Brant, Illkirch, 67412 Strasbourg, France
4CNRS, Cognitive and Adaptive Neurosciences Laboratory (UMR 7364), University of Strasbourg, 12 rue Goethe, 67000 Strasbourg, France
5Service of Radiology, Unity of Neuropsychology, University Hospital of Strasbourg, 1 avenue Molière, 67000 Strasbourg, France

Received 9 November 2014; Revised 8 January 2015; Accepted 9 January 2015

Academic Editor: Giuseppe Curcio

Copyright © 2015 Nathalie Philippi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We compared specific (i.e., associated with a unique time and space) and general (i.e., extended or repeated events) autobiographical memories (AbM) in Alzheimer’s disease (AD). The comparison aims at investigating the relationship between these two components of AbM across the lifespan and the volume of cerebral regions of interest within the temporal lobe. We hypothesized that the ability to elicit specific memories would correlate with hippocampal volume, whereas evoking general memories would be related to lateral temporal lobe. AbM was assessed using the modified Crovitz test in 18 patients with early AD and 18 matched controls. The proportions of total memories—supposed to reflect the ability to produce general memories—and specific memories retrieved were compared between AD patients and controls. Correlations to MRI volumes of temporal cortex were tested. We found different temporal patterns for specific and general memories in AD patients, with (i) relatively spared general memories, according to a temporal gradient that preserved remote memories, predominantly associated with right lateral temporal cortex volume. (ii) Conversely, the retrieval of specific AbMs was impaired for all life periods and correlated with bilateral hippocampal volumes. Our results highlight a shift from an initially episodic to a semantic nature of AbMs during AD, where the abstracted form of memories remains.