Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease

Figure 1

The frequency of entry to the inner area in an elevated open space with a novel object (for anxiety status) of different experimental groups of rats. versus control/sham operated rats at day 14 (), versus control/sham operated rats at day 21 (), versus etoricoxib treated cAD at all the doses at day 14 (), and versus etoricoxib treated cAD at all the doses at day 21 (). AD: intracerebroventricular colchicine injected Alzheimer Disease rats, AD + E (10): AD rats treated with 10 mg/kg body weight of etoricoxib, AD + E (20): AD rats treated with 20 mg/kg body weight of etoricoxib, and AD + E (30): AD rats treated with 30 mg/kg body weight of etoricoxib. Values are expressed in mean ± SEM ( in each group).