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Behavioural Neurology
Volume 2016, Article ID 3189108, 6 pages
Research Article

Antiepileptic Drug Nonadherence and Its Predictors among People with Epilepsy

1Finote Selam Hospital, Finote Selam, Ethiopia
2Diseases Prevention and Control, School of Public Health, University of Queensland, Brisbane, QLD, Australia
3Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia
4College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia
5College of Health Sciences, Mizan Tepi University, Mizan, Ethiopia
6Psychiatry Department, College of Health Sciences and Medicine, Dilla University, Dilla, Ethiopia
7Debre Markos University, Debre Markos, Ethiopia
8College of Medicine and Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia

Received 7 June 2016; Accepted 16 November 2016

Academic Editor: Jesus Pastor

Copyright © 2016 Asmamaw Getnet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Antiepileptic drugs are effective in the treatment of epilepsy to the extent that about 70% of people with epilepsy can be seizure-free, but poor adherence to medication is major problem to sustained remission and functional restoration. The aim of this study was to assess the prevalence and associated factors of antiepileptic drug nonadherence. Methods. Cross-sectional study was conducted on 450 individuals who were selected by systematic random sampling method. Antiepileptic drug nonadherence was measured by Morisky Medication Adherence Scale (MMAS) and logistic regression was used to look for significant associations. Result. The prevalence of AEDs nonadherence was 37.8%. Being on treatment for 6 years and above [AOR = 3.47, 95% CI: 1.88, 6.40], payment for AEDs [AOR = 2.76, 95% CI: 1.73, 4.42], lack of health information [AOR = 2.20, 95% CI: 1.41,3.43], poor social support [AOR = 1.88, 95%, CI: 1.01, 3.50], perceived stigma [AOR = 2.27, 95% CI: 1.45, 3.56], and experience side effect [AOR = 1.70, 95% CI: 1.06, 2.72] were significantly associated with antiepileptic drug nonadherence. Conclusion. More than one-third of people with epilepsy were not compliant with their AEDs. Giving health information about epilepsy and its management and consequent reduction in stigma will help for medication adherence.