Cognitive Impairment Involving Social Cognition in SPG4 Hereditary Spastic Paraplegia
Table 1
Neuropsychological assessment of SPG4 participants.
Patient
Age
Sex
Level of education (years)
MMSE
Episodic memory
Semantic memory
Executive function
Attention
Language
Gnostic function
Praxis function
Social cognition
Number of altered domains
Age at disease onset (years)
Disease duration (years)
SDSF
FAIII3
68
f
5
27
X
X
X
3
NA
NA
0
FAIII4
64
m
4
19
X
X
X
3
45
19
4
FAIV1
45
f
9
28
X
1
12
33
5
FAIV2
50
m
10
25
X
X
X
3
44
6
2
FAIV3
43
m
10
27
X
X
X
X
4
30
13
3
FBIII1
50
f
11
30
X
X
X
3
42
8
3
FBIII2
50
f
11
30
X
X
X
X
4
38
12
4
FCIII1
54
f
9
26
X
X
X
3
20
34
3
FDIII1
44
f
11
26
X
X
2
40
4
2
SDSF: spinocerebellar degeneration functional score, NA: not applicable, f: female, m: male, and MMSE: mini-mental state examination. A cross means an impairment of the cognitive function.
