Human Neural Stem Cells Overexpressing Choline Acetyltransferase Restore Unconditioned Fear in Rats with Amygdala Injury

Figure 3

Locomotor activity of rats that encountered cat odor (a–c) and acetylcholine concentration (d). Spontaneous movements (resting and slow-moving and fast-moving times) were analyzed immediately before (a) and 2 weeks (b) and 4 weeks (c) after F3.ChAT cell transplantation following N-methyl-D-aspartate (NMDA) injection (−2 weeks), and acetylcholine was analyzed in cerebrospinal fluid 4 weeks after transplantation (d). White, normal environment (without cat odor) + vehicle (saline for NMDA and cells); red, cat odor + vehicle; green, cat odor + NMDA + vehicle; yellow, cat odor + NMDA + F3.ChAT cells. different from normal control (). different from vehicle control (). different from NMDA alone ().

(a)

(b)

(c)

(d)