Laser Evoked Potentials in Early and Presymptomatic Huntington’s Disease

Table 2

Laser evoked potentials features, including laser pain threshold and subjective perception (expressed by visual analog scale (VAS) from 0 to 100) in Huntington’s disease (HD) subjects, presymptomatic Huntington’s disease (PHD) subjects, and normal controls (N). The results of one-way ANOVA and post hoc Bonferroni test are reported. Significant results are reported in bold font.

Diagnosis	Pain threshold (Watt)	VAS	N1 (msec)	N1 (V)	N2 (msec)	P2 (msec)	N2P2 (V)
HD: 43
Mean	13.5	45	202.45	3.77	250.628	351.69	8.74
SD	5.5	22.2	32.241	2.31	47.76	66.73	6.06
N: 64
Mean	13.1	43.05	171.00	4.68	227.82	320.13	17.26
SD	4.8	24.46	31.128	3.12	23.68	27.06	11.68
PHD: 10
Mean	12.9	41.3	185.30	4.20	241	346.1	14.22
SD	5.6	19.14	26.403	3.85	32.9	42.77	11.82
ANOVA (age as covariate)
		0.98	7.16	1.73	5.52	5.63	5.83
DF		2	2	2	2	2	2
		ns	0.001	ns	0.005	0.005	0.004
Bonferroni
N versus HD patients		ns	0.001	ns	0.004	0.004	0.003
N versus PHD patients		ns	ns	ns	ns	ns	ns
HD patients versus PHD patients		ns	ns	ns	ns	ns	ns