Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection

Figure 2

Inflammatory infiltrates in the BS of HSV1-infected B6 mice. Mononuclear cells isolated from BS of PBS- (blue), ACV- (green), or IVIG + ACV- (red) treated HSV1 bilaterally infected mice at day 7 pi were analyzed for (a) % CD45^hi infiltrates, left y-axis (bars) and absolute cell numbers, right y-axis (circles) and (b) CD45^high CD11b⁺ monocyte/macrophages. (c) CD45^high CD11b⁺ Ly6C^high IM. (d) BS cell subsets in HSV1 unilaterally infected mice. (e) CD8 and (f) CD4 T cells in the BS of bilaterally infected mice treated with PBS, ACV, or ACV + IVIG (-5 mice/group).

(a) BE CD45^high

(b) BE CD11b⁺

(c) BE Ly6C⁺ IM

(d) SE BS Cells

(e) BE CD8

(f) BE CD4