Efficacy of a Computer-Assisted Cognitive Rehabilitation Intervention in Relapsing-Remitting Multiple Sclerosis Patients: A Multicenter Randomized Controlled Trial
Table 1
Demographic and clinical characteristics of the sample at baseline.
MS RehaCom group () Mean (95% CI) n (%)
SD
MS control group () Mean (95% CI) n (%)
SD
t/U x2
df
Age (years)
46.03 (43.16–48.90)
7.97
45.15 (41.26–49.05)
9.65
0.379
56
0.706
Education (years)
12.12 (10.87–13.38)
3.47
12.73 (11.46–14.01)
3.15
−0.945
0.345
Gender
Males
10 (31.25)
8 (30.76)
Females
22 (68.75)
18 (69.24)
0.002
1
0.969
EDSS-median (range)
3.0 (1.5–5.5)
3.5 (1.0–5.0)
−0.126
0.899
Disease duration (years)
13.31 (11.46–15.17)
11.27 (9.39–13.14)
−1.515
0.130
MMSE
27.97 (27.54–28.39)
1.17
28.42 (28.06–28.79)
0.90
−1.578
0.115
WASI (IQ)
102.31 (99.49–105.14)
7.83
103.96 (100.37–107.55)
8.89
−.959
0.338
Premorbid intelligence
WASI (Voc)
46.2
−0.785
0.680
T-score
45.5
Fatigue (FSS)
4.38 (4.04–4.48)
1.80
4.35 (3.98–4.55)
1.75
−0.297
0.486
BDI-FS
4.31 (3.31–5.32)
2.78
4.46 (3.01–5.91)
3.09
0.178
56
0.859
Medication at enrolment
Interferon
25 (78.12)
17 (65.38)
Fingolimod
2 (6.25)
3 (11.53)
Natalizumab
5 (15.63)
6 (23.07)
Notes: All values are raw scores. EDSS: Expanded Disability Status Scale; MMSE: Mini Mental State Examination; WASI: Wechsler Abbreviated Scale of Intelligence; WASI (VOC): vocabulary subscale of the Wechsler Abbreviated Scale of Intelligence; FSS: Fatigue Severity Scale; BDI-FS: Beck Depression Inventory-Fast Screen; SD; standard deviation; CI: confidence interval; df: degrees of freedom; t: independent sample t-test; U: Mann–Whitney U test; x2; chi-squared.
