Efficacy of a Computer-Assisted Cognitive Rehabilitation Intervention in Relapsing-Remitting Multiple Sclerosis Patients: A Multicenter Randomized Controlled Trial

Table 4

Comparison of neuropsychological test scores for the RehaCom MS-treated group at baseline, posttreatment, and at 6-month follow-up.

	Baseline		Posttreatment		6-month follow-up		Baseline versus posttreatment; values	Effect size (r)	Baseline versus follow-up; values
	Mean	Median	Mean	Median	Mean	Median
SRTLTS	36.72	36.50	43.47	41.00	43.00	41.00	0.000	0.539	0.000
SRTDR	6.09	6.50	8.22	8.00	7.75	7.00	0.000	0.481	0.001
BVMT-RT	21.40	21.00	24.50	23.90	23.10	23.00	0.000	0.469	0.001
VFT phon	31.88	32.00	33.13	33.50	31.47	31.50	ns	—	ns
VFT sem	41.03	40.00	43.56	42.00	42.06	40.50	0.003	0.417	0.424
SDMT	36.91	36.00	40.03	39.00	37.50	37.00	0.000	0.522	0.222
TMT-A	73.50	70.00	59.53	62.50	60.31	66.00	0.000	0.573	0.000
TMT-B	145.81	32.50	113.28	106.50	115.78	107.50	0.000	0.506	0.000
SNST	59.80	58.50	63.50	62.90	62.10	60.40	0.000	0.460	0.000

Notes: All values are raw scores ( and ). Friedman’s nonparametric test used for comparison of medians between baseline, posttreatment, and follow-up. Wilcoxon test with Holm-Bonferroni correction used for pairwise comparisons. Effect size (r) for Wilcoxon test calculated as follows: ; abs (r) 0.1 small size; 0.3 medium size; 0.5 large size; ns: Friedman’s test indicated no significant group effect for VFT phon. SRTLTS: Selective Reminding Test Long-Term Storage; SRTDR: Selective Reminding Test-Delayed Recall; BVMT-RT: Brief Visuospatial Memory Test-Revised Total Recall; VFT phon: Greek Verbal Fluency Test-Phonemic Fluency; VFT sem: Greek Verbal Fluency Test-Semantic Fluency; SDMT: Symbol Digit Modalities Test; TMT-A and TMT-B: Greek Trail Making Test Part A and Greek Trail Making Test Part B; SNST: Stroop Neuropsychological Screening Test.