Neuroprotective and Antiamnesic Effects of Mitragyna inermis Willd (Rubiaceae) on Scopolamine-Induced Memory Impairment in Mice

Table 2

Effect of M. inermis in scopolamine-induced cognitive deficit mice in EPM.

Treatments	Transfer latency (seconds)		Inflexion ratio
	8th day	9th day
H2O + Scop	62.4 ± 2.6	57.2 ± 1.8^c	0.09^c
39.3 + Scop	63.2 ± 7.04	39.0 ± 2.4	0.62
98.25 + Scop	65.4 ± 5.12	37.8 ± 2.16	0.73
196.5 + Scop	68.8 ± 2.96	36.2 ± 2.16	0.90
393 + Scop	63.6 ± 2.32	46.4 ± 1.92	0.37
Pira + Scop	63.4 ± 4.72	38.6 ± 2.08	0.64
H2O + H2O	69.6 ± 8.32	40.2 ± 1.44	0.73

Data are mean ± SD, per dose. , , and , compared to scopolamine-treated group (H2O + Scop), one-way ANOVA followed by Dunnett’s bilateral comparisons for TL, and Duncan’s test for IR. ^c compared to normal control group (H2O + H2O), one-way ANOVA followed by Dunnett’s bilateral comparisons for TL, and Duncan’s test for IR. H2O: distilled water, Pira: piracetam 200 mg/kg, Scop: scopolamine 0.4 mg/kg.