Neuroprotective and Antiamnesic Effects of Mitragyna inermis Willd (Rubiaceae) on Scopolamine-Induced Memory Impairment in Mice

Table 4

Effect of M. inermis in scopolamine-induced cognitive deficit mice in ORT.

Treatments	Exploration time (seconds)			Discrimination index
	Session 1	Session 2
		N	F
H2O + Scop	31.4 ± 2.1	21.2 ± 0.64^c	18 ± 1.2^c	0.08^c
39.3 + Scop	38.2 ± 1.8	36.2 ± 3.0	13.8 ± 0.7	0.45
98.25 + Scop	34.8 ± 2.6	38.0 ± 1.6	11.4 ± 1.3	0.54
196.5 + Scop	38.0 ± 3.6	40.2 ± 3.0	9.6 ± 1.9	0.61
393 + Scop	32.0 ± 3.2	32.0 ± 2.8	10.8 ± 1.4	0.49
Pira + Scop	33.0 ± 2.8	35.4 ± 2.5	11.8 ± 1.5	0.50
H2O + H2O	30.0 ± 1.6	36.0 ± 3.6	11.2 ± 1.1	0.52

Data are mean ± SD, per dose. , , and , compared to scopolamine-treated group (H2O + Scop), one-way ANOVA followed by Dunnett’s bilateral comparisons for exploration time, and Duncan’s test for discrimination index. ^c compared to normal control group (H2O + H2O), one-way ANOVA followed by Dunnett’s bilateral comparisons for exploration time, and Duncan’s test for discrimination index. F: familiar object, H2O: distilled water, N: novel object, Pira: piracetam 200 mg/kg, Scop: scopolamine 0.4 mg/kg.