Neuroprotective and Antiamnesic Effects of Mitragyna inermis Willd (Rubiaceae) on Scopolamine-Induced Memory Impairment in Mice

Table 5

Effect of M. inermis in scopolamine-induced cognitive impairment mice in MWM.

Doses	Escape latency (seconds)				Time spent in target quadrant (seconds)
	Day 1	Day 2	Day 3	Day 4
H2O + Scop	105 ± 7.5	90.4 ± 9.8	65.4 ± 7.4	48.2 ± 3.7^b	50.6 ± 2.9^b
39,3 + Scop	108.8 ± 6.8	90.8 ± 10.6	65.6 ± 7.0	44.6 ± 3.4	53.0 ± 3.5
98,25 + Scop	101.8 ± 10.8	95 ± 9.9	65.4 ± 6.9	41.0 ± 1.6	63.2 ± 2.6
196,5 + Scop	104.6 ± 7.5	91.6 ± 7.7	53.2 ± 6.1	32.2 ± 1.9	68.4 ± 2.7
393 + Scop	98 ± 5.8	86 ± 9.9	50 ± 7.3	39.8 ± 1.3	64.8 ± 3.8
Pira + Scop	105.4 ± 8.9	85.4 ± 7.4	53.8 ± 9.6	41.6 ± 2.7	66.0 ± 2.6
H2O + H2O	101 ± 7.8	86.2 ± 6.3	62.8 ± 7.7	41.2 ± 1.3	65.4 ± 3.2

Data are mean ± SD, per dose. , and , compared to scopolamine treated group (H2O + Scop), one-way ANOVA followed by Dunnett’s bilateral comparisons. ^b compared to normal control group (H2O + H2O), one-way ANOVA followed by Dunnett’s bilateral comparisons. H2O: distilled water, Pira: piracetam 200 mg/kg, Scop: scopolamine 1 mg/kg.