Research Article
Neuroprotective and Antiamnesic Effects of Mitragyna inermis Willd (Rubiaceae) on Scopolamine-Induced Memory Impairment in Mice
| Escape latency day 1 | Mice/doses | H2O + Scop | 39.3 + Scop | 98.25 + Scop | 196.5 + Scop | 393 + Scop | Pira + Scop | H2O + H2O | 1 | 110 | 112 | 101 | 107 | 89 | 112 | 102 | 2 | 112 | 110 | 91 | 111 | 105 | 100 | 114 | 3 | 109 | 102 | 97 | 109 | 99 | 107 | 94 | 4 | 95 | 118 | 120 | 104 | 97 | 93 | 98 | 5 | 99 | 102 | 100 | 92 | 100 | 115 | 97 | Means | 105 | 108.8 | 101.8 | 104.6 | 98 | 105.4 | 101 | SD | 7.51664819 | 6.87022561 | 10.894953 | 7.50333259 | 5.83095189 | 8.96102673 | 7.81024968 |
| Escape latency day 2 | Mice/doses | H2O + Scop | 39.3 + Scop | 98.25 + Scop | 196.5 + Scop | 393 + Scop | Pira + Scop | H2O + H2O | 1 | 84 | 95 | 102 | 97 | 101 | 79 | 83 | 2 | 90 | 80 | 99 | 100 | 89 | 89 | 95 | 3 | 78 | 102 | 92 | 80 | 78 | 93 | 78 | 4 | 98 | 98 | 103 | 89 | 76 | 90 | 86 | 5 | 102 | 79 | 79 | 92 | 86 | 76 | 89 | Means | 90.4 | 90.8 | 95 | 91.6 | 86 | 85.4 | 86.2 | SD | 9.8386991 | 10.6160256 | 9.92471662 | 7.76530746 | 9.97496867 | 7.43639698 | 6.37965516 |
| Escape latency day 3 | Mice/doses | H2O + Scop | 39.3 + Scop | 98.25 + Scop | 196.5 + Scop | 393 + Scop | Pira + Scop | H2O + H2O | 1 | 70 | 67 | 57 | 62 | 53 | 53 | 62 | 2 | 72 | 65 | 59 | 57 | 50 | 56 | 62 | 3 | 65 | 72 | 72 | 49 | 60 | 67 | 57 | 4 | 53 | 54 | 71 | 47 | 47 | 40 | 76 | 5 | 67 | 70 | 68 | 51 | 40 | 53 | 57 | Means | 65.4 | 65.6 | 65.4 | 53.2 | 50 | 53.8 | 62.8 | SD | 7.43639698 | 7.02139587 | 6.94982014 | 6.18061486 | 7.38241153 | 9.62808392 | 7.79102047 |
| Escape latency day 4 | Mice/doses | H2O + Scop | 39.3 + Scop | 98.25 + Scop | 196.5 + Scop | 393 + Scop | Pira + Scop | H2O + H2O | 1 | 43 | 49 | 41 | 31 | 41 | 38 | 43 | 2 | 50 | 46 | 40 | 32 | 38 | 42 | 40 | 3 | 48 | 45 | 43 | 35 | 41 | 40 | 42 | 4 | 53 | 43 | 39 | 30 | 39 | 45 | 41 | 5 | 47 | 40 | 42 | 33 | 40 | 43 | 40 | Means | 48.2 | 44.6 | 41 | 32.2 | 39.8 | 41.6 | 41.2 | SD | 3.7013511 | 3.36154726 | 1.58113883 | 1.92353841 | 1.30384048 | 2.70185122 | 1.30384048 |
| Time spent in target quadrant | Mice/doses | H2O + Scop | 39.3 + Scop | 98.25 + Scop | 196.5 + Scop | 393 + Scop | Pira + Scop | H2O + H2O | 1 | 48 | 51 | 61 | 71 | 62 | 65 | 65 | 2 | 50 | 55 | 60 | 68 | 65 | 63 | 67 | 3 | 55 | 49 | 66 | 70 | 68 | 65 | 70 | 4 | 48 | 58 | 64 | 69 | 60 | 67 | 63 | 5 | 52 | 52 | 65 | 64 | 69 | 70 | 62 | Means | 50.6 | 53 | 63.2 | 68.4 | 64.8 | 66 | 65.4 | SD | 2.96647939 | 3.53553391 | 2.58843582 | 2.70185122 | 3.8340579 | 2.64575131 | 3.20936131 |
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