Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study
Table 2
Between-group differences in subcortical rs-fMRI measures and volumes; mean (SD).
Region
Measure
Left hemisphere
Right hemisphere
NC
MCI
NC
MCI
Thalamus
ALFF
2.85 ± 0.97
2.41 ± 0.95
0.97
0.34
2.80 ± 0.95
2.37 ± 0.89
1.12
0.27
fALFF
0.337 ± 0.039
0.323 ± 0.042
0.69
0.50
0.335 ± 0.039
0.323 ± 0.042
1.38
0.18
ReHo
0.150 ± 0.029
0.135 ± 0.027
2.00
0.05
0.149 ± 0.030
0.134 ± 0.026
2.24
0.03
Volume
7.08 ± 1.12
7.08 ± 1.17
0.09
0.93
6.88 ± 0.95
6.86 ± 1.05
0.14
0.89
Caudate
ALFF
2.35 ± 0.84
2.05 ± 0.82
0.51
0.61
2.27 ± 0.81
1.96 ± 0.78
0.49
0.62
fALFF
0.335 ± 0.039
0.326 ± 0.039
−0.18
0.86
0.336 ± 0.039
0.327 ± 0.040
−0.53
0.60
ReHo
0.135 ± 0.028
0.135 ± 0.019
0.52
0.60
0.141 ± 0.037
0.139 ± 0.023
0.50
0.62
Volume
3.05 ± 0.57
3.18 ± 0.39
0.16
0.87
3.35 ± 0.53
3.37 ± 0.38
0.29
0.07
Putamen
ALFF
2.41 ± 0.83
2.12 ± 0.86
−0.22
0.83
2.26 ± 0.85
1.98 ± 0.76
0.52
0.61
fALFF
0.335 ± 0.038
0.324 ± .039
0.02
0.98
0.335 ± 0.037
0.323 ± 0.040
1.55
0.13
ReHo
0.134 ± 0.025
0.132 ± .022
0.85
0.40
0.146 ± 0.035
0.134 ± 0.024
1.45
0.16
Volume
4.40 ± 0.96
4.55 ± 0.73
0.62
0.54
4.36 ± 0.80
4.50 ± 0.71
0.12
0.90
Pallidum
ALFF
2.55 ± 0.87
2.23 ± 0.91
−0.03
0.97
2.27 ± 0.91
2.11 ± 0.82
0.71
0.48
fALFF
0.328 ± 0.039
0.321 ± 0.041
−0.40
0.69
0.334 ± 0.038
0.321 ± 0.041
1.84
0.07
ReHo
0.125 ± 0.026
0.117 ± 0.028
0.92
0.36
0.137 ± 0.032
0.116 ± 0.031
2.23
0.04
Volume
1.86 ± 0.51
1.82 ± 0.37
−0.03
0.97
1.81 ± 0.46
1.83 ± 0.38
−0.73
0.47
Hippocampus
ALFF
3.22 ± 1.29
2.58 ± 1.03
0.74
0.46
3.00 ± 1.06
2.48 ± 1.00
1.08
0.28
fALFF
0.328 ± 0.037
0.323 ± 0.043
0.52
0.61
0.338 ± 0.035
0.321 ± 0.044
1.19
0.24
ReHo
0.131 ± 0.025
0.125 ± 0.026
1.73
0.09
0.135 ± 0.025
0.118 ± 0.026
2.75
0.01
Volume
3.14 ± 0.67
3.41 ± 0.54
−1.23
0.23
3.47 ± 0.83
3.57 ± 0.51
−0.18
0.86
Amygdala
ALFF
3.23 ± 1.30
2.58 ± 1.00
0.31
0.76
2.91 ± 0.99
2.47 ± 0.93
0.92
0.38
fALFF
0.335 ± 0.036
0.324 ± 0.042
0.11
0.92
0.339 ± 0.033
0.325 ± 0.039
0.84
0.41
ReHo
0.126 ± 0.024
0.121 ± 0.029
1.36
0.18
0.132 ± 0.029
0.112 ± 0.029
2.98
0.01
Volume
1.05 ± 0.38
1.02 ± 0.29
−0.72
0.47
1.15 ± 0.26
1.16 ± 0.23
−0.31
0.76
Accumbens
ALFF
2.61 ± 0.88
2.27 ± 0.87
0.09
0.93
2.60 ± 0.96
2.23 ± 0.85
0.63
0.53
fALFF
0.336 ± 0.038
0.325 ± 0.040
−0.20
0.84
0.338 ± 0.044
0.323 ± 0.043
0.20
0.84
ReHo
0.124 ± 0.034
0.118 ± 0.024
1.17
0.25
0.129 ± 0.033
0.118 ± 0.030
0.75
0.46
Volume
0.42 ± 0.17
0.42 ± 0.14
0.87
0.39
0.27 ± 0.14
0.31 ± 0.10
−0.12
0.90
The subcortical volumes are described in milliliter (ml). The rs-fMRI measures are in natural units. value is from two sample t-tests adjusted for age, gender, scanner type, and years of education (and intracranial volume for all subcortical volumes). Positive value indicates NC > MCI. .
