Gait and Conditioned Fear Impairments in a Mouse Model of Comorbid TBI and PTSD

Figure 1

Experimental design and timeline. Subjects were randomized to SPS or no treatment. Mice were then further randomized to receive either a CCI or sham surgery to result in our four studied groups: control, TBI, PTSD, and TBI + PTSD. Behavioral testing in experiment 1 began 72 hours after surgeries with one day of gait testing, then 72 hours later began three days of contextual fear conditioning. Experiment 2 consisted of 1 day of PPI testing 72 hours after surgeries.