Gait and Conditioned Fear Impairments in a Mouse Model of Comorbid TBI and PTSD

Figure 4

Comorbid TBI + PTSD does not affect acoustic startle response or prepulse inhibition. (a) Schematic of experimental design, acoustic testing chamber, and startle protocol. (b) Acoustic startle response. There were no changes in acoustic startle response across groups when the 120 dB pulse was played without a prepulse. (c) Prepulse inhibition. There was a significant interaction between prepulse level and treatment group on inhibition of the startle response to the pulse; however, there were no group differences in overall PPI. Background noise was constantly generated at 65 dB. Error bars ± SEM. dB = decibel.

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