Functional Connectivity Changes in Behavioral, Semantic, and Nonfluent Variants of Frontotemporal Dementia
Table 2
Clinical findings in patients and healthy controls.
Controls
nfvPPA
svPPA
bvFTD
value
Post hoc
MOCA
26.32 (2.57)
8.73 (7.26)
8.8 (6.58)
15.61 (7.53)
<0.001
1, 2, 3
MMSE
28.86 (1.27)
16.9 (6.92)
16.67 (7.66)
22.47 (6.5)
<0.001
1, 2, 3
IFS
22.3 (3.37)
6.20 (6.06)
10.8 (6.94)
10.7 (6.76)
<0.001
1, 2
Hayling
—
22.1 (11.09)
18 (13.52)
24.19 (12.66)
0.607
—
Errors WSCT
10.64 (8.14)
28 (7.77)
29.63 (8.88)
21.5 (10.18)
<0.001
1
ROFC
32.66 (5.05)
17.2 (11.86)
27.89 (9.35)
20.79 (12.26)
<0.001
1
FrSBe before
—
77.13 (18.63)
74.91 (29.39)
71.67 (18.79)
0.136
—
FrSBe currently
—
121.47 (32.22)
130.73 (42.66)
129.15 (31.65)
0.449
—
FrSBe apathy before
—
21.69 (4.92)
21 (10.28)
21.14 (7.57)
0.969
—
FrSBe apathy currently
—
46.46 (11.44)
46.55 (16.9)
44 (12.46)
0.76
—
FrSBe inhibition before
—
23.15 (5.68)
22.55 (9.17)
20.65 (5.36)
0.391
—
FrSBe inhibition currently
—
28.54 (7.66)
31.18 (10.05)
32.46 (11.46)
0.516
—
FrSBe DE before
—
32.08 (11.95)
31.27 (13.14)
29.38 (9.62)
0.702
—
FrSBe DE currently
—
50.92 (16.09)
52.55 (17.31)
53.95 (15.28)
0.833
—
Semantic fluency
16.68 (3.58)
5.91 (2.86)
4.20 (3.47)
10.45 (5.26)
<0.001
1, 2, 3
Phonological fluency
14.93 (5.05)
4.69 (3.31)
3.83 (2.79)
9.75 (5.47)
<0.001
1, 2, 3
Proverbs
8.54 (2.05)
2.53 (3.06)
1.4 (2.37)
4.09 (3.49)
<0.001
1
Mean and standard deviation were reported. value from ANOVA. FrSBe DE: FrSBe dysfunction executive; nfvPPA: primary nonfluent aphasia; svPPA: semantic dementia; BV: behavioral variant; post hoc with Holm-Sidak (<0.05); 1: controls ≠ (bvFTD or svPPA or nfvPPA); 2: bvFTD ≠ nfvPPA; 3: bvFTD ≠ svPPA; 4: svPPA ≠ nfvPPA.
