Short-Term Neurodevelopmental Outcome in Term Neonates Treated with Phenobarbital versus Levetiracetam: A Single-Center Experience

Table 4

Source	Study type	Population	Gender distribution	Primary LEV	Secondary LEV	Loading dose	Maintenance dose	Other AED
Hmaimess et al. (2006)	Case report	Term neonate	1M	0	1	10 mg/kg	30 mg/kg	PHT, CLZ, PB, MDZ, LMT
Shoemaker and Rotenberg (2007)	Case report	Preterm/term	1F/2M	0	3	60 mg/kg	30 mg/kg	PB, PHT, MDZ
Abend et al. (2011)	Retrospective	Preterm/term neonates	11M/12F	4	19	10-20 mg/kg	5-40 mg/kg	PB, PHT, TPM, MDZ, FA
Ramantani et al. (2011)	Prospective	Preterm/term neonates	24M/14F	38	0	10 mg/kg	Up to 60 mg/kg	Up to 2 doses of PB 20 mg/kg
Khan et al. (2011) [43]	Retrospective	Term neonates	10M/12F	3	19	10-50 mg/kg	25 mg/kg	PB, FP, LZP, MDZ
Khan et al. (2013)	Retrospective	Preterm neonates	4M/7F	3	8	25-50 mg/kg	25 mg/kg	PB
Rakshasbhuvankar et al. (2013)	Case series	Preterm/term neonates	5M/3F	0	8	5-10 mg/kg	10-35 mg/Kg	PB, CZP, TPM, OXC
Yau et al. (2015)	Retrospective	Preterm/term neonates		0	12	7-20 mg/kg	5-60 mg/kg	PHT, TPM
Falsaperla et al. (2017)	Prospective	Preterm/term neonates		16	0	10 mg/kg	Up to 40 mg/kg	PB

Legend: CLZ: clonazepam; FA: folinic acid; FP: fosphenytoin; LZP: lorazepam; MDZ: midazolam; OXC: oxcarbazepine; PB: phenobarbital; PHT: phenytoin; TPM: topiramate.