Behavioural Neurology / 2019 / Article / Tab 1

Research Article

Depression and Temporal Lobe Epilepsy: Expression Pattern of Calbindin Immunoreactivity in Hippocampal Dentate Gyrus of Patients Who Underwent Epilepsy Surgery with and without Comorbid Depression

Table 1

Clinical data of patients with TLE with and without comorbid depression ().

Case numberSexAge of seizure onsetAge of surgeryTime of epilepsy durationRMNType of depression DSM-IVSuicide attemptsPsychopharms receivedAntiepileptic treatmentGAFBeck inventoryMemory deficitsHippocampal sclerosis typeDentate gyrus pathology% of CB-IR-sprouted cells

1M94233RHSNoNoNoDFH, TPM65n/aGMDIYes
2M18246RHSNoNoNoCZP, CL70n/aViMDIYes
3F22826RHSRMD+PNoAD, RPCZP, VPA, CL55n/aViMDIYes
4F82416LHSMD+PYesFLX, RPCBZ, LMT70n/aGMDIYes
5F234118LHSNoNoNoTPM, CBZ, CL60n/aVMDINo
6F174629RHSNoNoNoCBZ, TPM70n/aViMDINo
7F324715RHSNoNoNoCBZ, CL70n/aViMDIYes
8F32219RHSRMDYesCTLMT, CBZ65n/aNormalINo
9F133623RHSRMD+DNoADCZP, CL5523NormalIYes
10F72215RHSNoNoNoCBZ, TPM708ViMDIYes
11F15183RHSNoNoNoCBZ, LTG8013NormalIYes
12F14140LHSNoNoNoDFH, CBZ, LVT7010NormalIYes
13M122210RHSNoNoNoDFH, LMT, CL606ViMDIYes
14M14039LHSNoNoNoVPA, CL704NormalIYes
15F112918LHSNoNoNoCBZ, CL656ViMDIYes
16M253712LHSNoNoNoCBZ, TPM, CL858ViMDIIYes
17F102414LHSRMDNoSTLMT, CBZ6521GMDIYes
18M61711RHSMDNoNoOXC, LVT, CL7029VMDIYes
19F18246RHSMDNoNoCBZ, CL809VMDIYes
20F13938LHSMD+DNoNoLMT, LCS655NormalIYes
21F175235LHSRMD+DNoADLMT, LVT, CL5524NormalIYes
22F51813LHSDNoNoOXC, CL651VMDIINo
23M82517LHSRMD+DNoNoTPM, CBZ, FT5520GMDIYes
24F23434LHSRMD+PYesST, OLN, RP, LSDVPA, FB, CBZ5022GMDIYes

GAF: Global Assessment of Functioning (DSM-IV); RMD: recurrent major depression; MD: major depression; D: dysthymia; n/a: not available data; P: psychotic symptoms associated with depression; PPT: psychopharmacological treatment received during life; AD: antidepressants (not determined which one); FLX: fluoxetine; CT: citalopram; ST: sertraline; RP: risperidone; LSD: lurasidone; OLZ: olanzapine; AED: antiepileptic drug treatment; DPH: diphenylhydantoin; TPM: topiramate; CBP: carbamazepine; CL: clonazepam; VPA: divalproate; LMT: lamotrigine; LVT: levetiracetam; FB: phenobarbital; LCZ: lacosamide; HS: hippocampal sclerosis—type I (CA1+CA4 predominantly affected) and type II (CA1 predominantly affected); VMD: verbal memory deficit, ViMD: visuospatial memory deficit; GMD: global memory deficit. Dentate gyrus pathology according to Blümcke et al. [13]. The % CB+ sprouted cells: is <10, is ≤15 but >10% is ≤20 but >15%, and is >20% of CB IR.

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