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Behavioural Neurology
Volume 2019, Article ID 7470904, 7 pages
Research Article

Probable RBD Associates with the Development of RLS in Parkinson’s Disease: A Cross-Sectional Study

1Department of Neurology, The First Hospital of Harbin Medical University, Harbin, China
2Department of Neurology, Daqing Oilfield General Hospital, Daqing, China
3Department of Neurology, The Fourth Hospital of Harbin Medical University, Harbin, China
4Zuckerman Mind Brain Behavior Institute, Columbia University, New York, USA
5State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China

Correspondence should be addressed to Yujun Pan; nc.ude.umbrh.sme@napnujuy

Received 17 October 2018; Revised 21 January 2019; Accepted 18 February 2019; Published 1 April 2019

Academic Editor: Luigi Ferini-Strambi

Copyright © 2019 Yewei Qu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. We aimed to investigate the prevalence of restless leg syndrome (RLS) and exploring the contributing factors that affect the development of RLS in Parkinson’s disease (PD) patients. Methods. A cross-sectional study was conducted consisting of 178 consecutive PD patients from our hospital between October 2015 and August 2016. We divided the participants into two groups, which were PD with RLS and PD with non-RLS. Then, we recorded their demographics and clinical data to draw a comparison between PD with RLS and PD with non-RLS. Results. 23 (12.92%) were diagnosed with RLS among all the enrolled PD patients. Unified Parkinson’s Disease Rating Scale III (UPDRS III) and Hamilton Depression Scale (HAMD) scores, probable rapid eye movement sleep behavior disorder (PRBD), and daily levodopa equivalent dose (LED) in the PD with the RLS group were significantly different from those in the PD with the non-RLS group. Daily LED and the scores of UPDRS III and HAMD in PD patients with RLS were all higher than those in PD patients with non-RLS. PRBD, daily LED, and HAMD scores were significantly independent factors contributing to the development of RLS (, 95% CI 1.372~15.944, ; , 95% CI 1.001~1.005, ; , 95% CI 1.002~1.193, ). The severity of RLS was positively correlated with the duration of PD and daily LED (, ; , ). Conclusion. PRBD existence, daily LED, and HAMD scores are independent factors for developing RLS in PD patients. PRBD existence is firstly proposed as an independent factor in developing RLS among PD patients. RLS severity in PD patients are positively associated with the duration of PD and daily LED.