The Clinical and Vascular Characteristics of RNF213 c.14576G>A Variant-Related Intracranial Major Artery Disease in China

Figure 2

Images of HR-MMD and HR-ICAD patients with RNF213 c.14576G>A variant. (a–c) A 44-year-old woman with asymptomatic MMD, diagnosed as HR-MMD. TOF MRA showed the occlusion of the left MCA and moderate to severe stenosis of right MCA (a). A precontrast image of the right MCA reveals a small outer diameter with concentric wall thickening (b) and concentric enhancement on the vessel wall in a postcontrast image with collateral vessels (c). (d–f) A 36-year-old man with ICAD presented with cerebral infarction, diagnosed as HR-MMD. TOF MRA demonstrated severe stenosis of the left MCA (d). A precontrast image of the left MCA showed eccentric stenosis and a normal outer diameter (e) with eccentric plaque enhancement in a postcontrast image (f).