Antipsychotic Drugs Reverse MK801-Inhibited Cell Migration and F-actin Condensation by Modulating the Rho Signaling Pathway in B35 Cells

Figure 5

Effects of MK801, haloperidol (HAL), and clozapine (CLO) on N-WASP, PAK1, and ARP2/3 regulation in B35 cells. (a) Western blot revealing APD-induced changes in the expression of the N-WASP, PAK1, and ARP2/3 proteins in B35 cells. (b) Protein expression was quantified and normalized to beta-actin, and the relative expression of each protein chart bar was constructed from triplicate western blot data obtained from three different batches of APD-treated cells using ANOVA followed by Dunnett’s test ( value <0.05; value <0.01).

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