Protective Factors Modulate the Risk of Beta Amyloid in Alzheimer’s Disease

Table 2

The risk factors for conversion to AD by Cox regression.

Factors	Univariate	Multivariate
	Hazard ratio (95% CI)	Hazard ratio (95% CI)
Hippocampal volume	0.923 (0.913-0.934)	0.959 (0.933-0.985)
Average-brain FDG	0.867 (0.848-0.887)	0.884 (0.851-0.918)
Cortical thickness of the entorhinal cortex	0.903 (0.887-0.918)	0.941 (0.903-0.981)
Av45	1.468 (1.359-1.585)	1.244 (1.113-1.391)
Sex	0.835 (0.666-1.047)	0.534 (0.324-0.882)
ApoE4 (2)	4.502 (3.191-6.352)	2.063 (0.996-4.276)
(1)	2.892 (2.267-3.690)	2.024 (1.135-3.608)
(0)	Reference	Reference
Intracranial volume	1.082 (1.010-1.159)
Whole-brain volume	0.997 (0.996-0.998)
Fusiform volume	0.805 (0.765-0.846)
Ventricles	1.013(1.009-1.018)
Age	1.006 (0.990-1.023)
Education	0.971 (0.934-1.010)

. Av45: brain PET amyloid; FDG: CGM based on 18F-FDG-PET.