Basolateral Amygdala but Not Medial Prefrontal Cortex Contributes to Chronic Fluoxetine Treatments for PTSD Symptoms in Mice

Figure 1

The experimental procedure. After the 14-day adaptation phase, a 2-mA footshock for 10 seconds was applied for fear conditioning, and the freezing time was measured for 2 min during one session a day in the situational reminder sessions. Later, the mice’s floating behavior was measured for 5 min in the FST. Following the final session of freezing and floating behavior measurements, 120 mice were sacrificed, and their brain tissues were labeled using immunohistochemical staining with c-Fos proteins.