Research Article

Serum Glycoproteomics and Identification of Potential Mechanisms Underlying Alzheimer’s Disease

Table 3

Upregulated glycoproteins in the serum of the AD group (identified proteins from the UniProt Homo sapiens database).

Protein IDProtein nameMassGlycosylationPosttranslational modification

Q9UP79A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAM-TS 8) (ADAM-TS8) (ADAMTS-8) (EC 3.4.24.-) (METH-2) (METH-8)96,460N-linked (GlcNAc) asparaginePTM: the precursor is cleaved by a furin endopeptidase
B7ZC32Kinesin-like protein KIF28P (kinesin-like protein 6)108,254
Q9Y3C8Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1)19,458
P00742Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor) (cleaved into factor X light chain, factor X heavy chain, and activated factor Xa heavy chain)54,732O-linked (GalNAc) threoninePTM: the vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind to calcium
P20340Ras-related protein Rab-6A (Rab-6)23,593PTM: prenylated
Q9NRR8CDC42 small effector protein 1 (CDC42-binding protein SCIP1) (small effector of CDC42 protein 1)8,925
Q9NYH9U3 small nucleolar RNA-associated protein 6 homolog (hepatocellular carcinoma-associated antigen 66) (multiple hat domain protein)70,194
P1807760S ribosomal protein L35a (cell growth-inhibiting gene 33 protein) (large ribosomal subunit protein eL33)12,538
Q3SXY7Leucine-rich repeat, immunoglobulin-like domain, and transmembrane domain-containing protein 374,754N-linked (GlcNAc) asparaginePTM: glycosylated
Q9NUL5Shiftless antiviral inhibitor of ribosomal frameshifting protein (SFL) (SHFL) (interferon-regulated antiviral protein) (IRAV) (repressor of yield of DENV protein) (RyDEN)33,110
Q12788Transducin beta-like protein 3 (WD repeat-containing protein SAZD)89,035
O94854Uncharacterized protein KIAA0754135,148
Q9BXJ7Protein amnionless (cleaved into soluble protein amnionless)47,754N-linked (GlcNAc) asparaginePTM: N-glycosylated
Q09019Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (protein 59) (protein DMR-N9)70,438
Q02846Retinal guanylyl cyclase 1 (RETGC-1) (EC 4.6.1.2) (CG-E) (guanylate cyclase 2D, retinal) (rod outer segment membrane guanylate cyclase) (ROS-GC)120,059N-linked (GlcNAc) asparagine
Q3LHN2Keratin-associated protein 19-25,737
O95925Eppin (cancer/testis antigen 71) (CT71) (epididymal protease inhibitor) (protease inhibitor WAP7) (serine protease inhibitor-like with Kunitz and WAP domain 1) (WAP four-disulfide core domain protein 7)15,284
Q9NYW3Taste receptor type 2 member 7 (T2R7) (taste receptor family B member 4) (TRB4)36,550N-linked (GlcNAc) asparagine
Q6UWV2Myelin protein zero-like protein 325,989N-linked (GlcNAc) asparagine
Q9Y5X4Photoreceptor-specific nuclear receptor (nuclear receptor subfamily 2 group E member 3) (retina-specific nuclear receptor)44,692
Q6Y288Beta-1,3-glucosyltransferase (Beta3Glc-T) (EC 2.4.1.-) (beta 3-glucosyltransferase) (beta-3-glycosyltransferase-like)56,564N-linked (GlcNAc) asparagine
Q8TB45DEP domain-containing mTOR-interacting protein (DEP domain-containing protein 6)46,294PTM: phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2
Q9UPG8Zinc finger protein PLAGL2 (pleiomorphic adenoma-like protein 2)54,584
Q9HCG1Zinc finger protein 160 (zinc finger protein HZF5) (zinc finger protein Kr18) (HKr18)94,112
P30281G1/S-specific cyclin-D332,520PTM: polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation
A0A286YF01Small cysteine and glycine repeat-containing protein 7 (keratin-associated protein 28-7)8,951
O15539Regulator of G protein signaling 5 (RGS5)20,946
Q12979Active breakpoint cluster region-related protein97,598
Q96EN8Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (hMCS) (EC 2.8.1.9) (molybdenum cofactor sulfurtransferase)98,120
P13765HLA class II histocompatibility antigen, DO beta chain (MHC class II antigen DOB)30,822N-linked (GlcNAc asparagine
Q6L8H2Keratin-associated protein 5-3 (keratin-associated protein 5-9) (keratin-associated protein 5.3) (keratin-associated protein 5.9) (UHS KerB-like) (ultrahigh sulfur keratin-associated protein 5.3)22,106
P21941Cartilage matrix protein (Matrilin-1)53,701N-linked (GlcNAc) asparagine
Q6IFN5Olfactory receptor 7E24 (olfactory receptor OR19-14)38,279N-linked (GlcNAc) asparagine
Q96BH3Epididymal sperm-binding protein 1 (epididymal secretory protein 12) (hE12)26,106N-linked (GlcNAc) asparaginePTM: N-glycosylated
O95149Snurportin-1 (RNA U transporter 1)41,143
Q9BSJ5Uncharacterized protein C17orf80 (cell migration-inducing gene 3 protein) (human lung cancer oncogene 8 protein) (HLC-8)67,315
Q9H1E5Thioredoxin-related transmembrane protein 4 (thioredoxin domain-containing protein 13)38,952
Q8NCL4Polypeptide N-acetylgalactosaminyltransferase 6 (EC 2.4.1.41) (polypeptide GalNAc transferase 6) (GalNAc-T6) (pp-GaNTase 6) (protein-UDP acetylgalactosaminyltransferase 6) (UDP-GalNAc:polypeptide N-acetylgalacto saminyltransferase 6)71,159N-linked (GlcNAc) asparagine
Q4G112Heat shock factor protein 5 (HSF 5) (heat shock transcription factor 5) (HSTF 5)65,278
Q9Y6L6Solute carrier organic anion transporter family member 1B1 (liver-specific organic anion transporter 1) (LST-1) (OATP-C) (sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (solute carrier family 21 member 6)76,449N-linked (GlcNAc) asparagine
P55073Thyroxine 5-deiodinase (EC 1.21.99.3) (5DIII) (DIOIII) (type 3 DI) (type III iodothyronine deiodinase)33,947
Q9H694Protein bicaudal C homolog 1 (Bic-C)104,844