Research Article

Serum Glycoproteomics and Identification of Potential Mechanisms Underlying Alzheimer’s Disease

Table 4

Downregulated glycoproteins in the serum of the AD group (identified proteins from the UniProt Homo sapiens database).

Protein IDProtein namesMassGlycosylationPosttranslational modification

Q9UBG0C-type mannose receptor 2 (C-type lectin domain family 13 member E) (endocytic receptor 180) (macrophage mannose receptor 2) (urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (urokinase receptor-associated protein) (CD antigen CD280)166,674N-linked (GlcNAc) (complex) asparaginePTM: N-glycosylated
Q96CS3FAS-associated factor 2 (protein ETEA) (UBX domain-containing protein 3B) (UBX domain-containing protein 8)52,623
Q9Y6E7NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (EC 2.3.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (NAD-dependent protein deacetylase sirtuin-4) (EC 2.3.1.286) (regulatory protein SIR2 homolog 4) (SIR2-like protein 4)35,188
Q8N6S4Ankyrin repeat domain-containing protein 13C60,818
Q9UHR4Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1) (insulin receptor tyrosine kinase substrate)56,883PTM: Phosphorylated on tyrosine in response to insulin
B2RUY7von Willebrand factor C domain-containing protein 2-like (Brorin-like)24,570
Q9Y3F4Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD)38,438
Q8TCV5WAP four-disulfide core domain protein 5 (putative protease inhibitor WAP1) (p53-responsive gene 5 protein)24,238
O60568Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (including procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (lysyl hydroxylase 3) (LH3); procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (galactosylhydroxylysine-glucosyltransferase) (procollagen galactosyltransferase)84,785N-linked (GlcNAc) asparagine
Q7Z7J5Developmental pluripotency-associated protein 2 (pluripotent embryonic stem cell-related gene 1 protein)33,784
Q8N6C5Immunoglobulin superfamily member 1 (IgSF1) (immunoglobulin-like domain-containing protein 1) (inhibin-binding protein) (InhBP) (pituitary gland-specific factor 2) (p120)148,936N-linked (GlcNAc) asparagine
Q04837Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17)17,260
Q7RTX1Taste receptor type 1 member 1 (G protein-coupled receptor 70)93,074N-linked (GlcNAc) asparagine
P13994Coiled-coil domain-containing protein 130 (9 kDa protein)44,802
Q5T440Putative transferase CAF17, mitochondrial (EC 2.1.-.-) (iron-sulfur cluster assembly factor homolog)38,155
A7E2S9Putative ankyrin repeat domain-containing protein 30B-like28,549
Q6QNK2Adhesion G protein-coupled receptor D1 (G protein-coupled receptor 133) (G protein-coupled receptor PGR25)96,530N-linked (GlcNAc) asparagine
Q8NBR0Tumor protein p53-inducible protein 13 (damage-stimulated cytoplasmic protein 1)42,238
A2VDJ0Transmembrane protein 131-like179,339N-linked (GlcNAc) asparagine
Q9NZT2Opioid growth factor receptor (OGFr) (protein 7-60) (zeta-type opioid receptor)73,325
P6291060S ribosomal protein L32 (large ribosomal subunit protein eL32)15,860
Q8WXI2Connector enhancer of kinase suppressor of ras 2 (connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2)117,535PTM: phosphorylated on tyrosine
O95396Adenylyltransferase and sulfurtransferase MOCS3 (molybdenum cofactor synthesis protein 3) (molybdopterin synthase sulfurylase) (MPT synthase sulfurylase) (including molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) (adenylyltransferase MOCS3) (sulfur carrier protein MOCS2A adenylyltransferase); molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) (sulfur carrier protein MOCS2A sulfurtransferase) (sulfurtransferase MOCS3))49,669
Q8IVN8Somatomedin-B and thrombospondin type-1 domain-containing protein (RPE-spondin)29,610N-linked (GlcNAc) asparagine
P55055Oxysterol receptor LXR-beta (liver X receptor beta) (nuclear receptor NER) (nuclear receptor subfamily 1 group H member 2) (ubiquitously expressed nuclear receptor)50,974PTM: sumoylated by SUMO2 at Lys-409 and Lys-447 during the hepatic acute phase response
Q7Z3I7Zinc finger protein 57261,238
Q9Y580RNA-binding protein 7 (RNA-binding motif protein 7)30,504PTM: phosphorylated at Ser-136 by MAPK14/p38-alpha-activated MAPKAPK2/MK2
P48729Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1)38,915
P19532Transcription factor E3 (class E basic helix-loop-helix protein 33) (bHLHe33)61,521PTM: phosphorylation by MTOR regulates its subcellular location and activity
Q8WXH4Ankyrin repeat and SOCS box protein 11 (ASB-11)35,367
Q86U42Polyadenylate-binding protein 2 (PABP-2) (poly(A)-binding protein 2) (nuclear poly(A)-binding protein 1) (poly(A)-binding protein II) (PABII) (polyadenylate-binding nuclear protein 1)32,749PTM: arginine dimethylation is asymmetric and involves PRMT1 and PRMT3
Q96MT1RING finger protein 145 (EC 2.3.2.27)75,617
P176435,6-Dihydroxyindole-2-carboxylic acid oxidase (DHICA oxidase) (EC 1.14.18.-) (catalase B) (glycoprotein 75) (melanoma antigen gp75) (tyrosinase-related protein 1) (TRP) (TRP-1) (TRP1)60,724N-linked (GlcNAc) asparaginePTM: glycosylated
Q9NW75G patch domain-containing protein 258,944
Q09472Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (histone butyryltransferase p300) (EC 2.3.1.-) (histone crotonyltransferase p300) (EC 2.3.1.-) (protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (protein lactyltransferase p300) (EC 2.3.1.-) (protein propionyltransferase p300) (EC 2.3.1.-)264,161PTM: acetylated on Lys at up to 17 positions by intermolecular autocatalysis
P58173Olfactory receptor 2B6 (Hs6M1-32) (olfactory receptor 2B1) (olfactory receptor 2B5) (olfactory receptor 5-40) (OR5-40) (olfactory receptor 6-31) (OR6-31) (olfactory receptor OR6-4)35,414N-linked (GlcNAc) asparagine
Q15776Zinc finger protein with KRAB and SCAN domains 8 (LD5-1) (zinc finger protein 192)65,816