Research Article

Serum Glycoproteomics and Identification of Potential Mechanisms Underlying Alzheimer’s Disease

Table 5

Glycoprotein classification in AD patients: upregulated and downregulated.

ClassificationPercentage

Upregulated glycoproteins
 Protein-binding activity modulator (PC00095)16.70%
 Gene-specific transcriptional regulator (PC00264)12.50%
 Metabolite interconversion enzyme (PC00262)12.50%
 Protein-modifying enzyme (PC00260)8.30%
 Transporter (PC00227)8.30%
 Nucleic acid metabolism protein (PC00171)8.30%
 Transmembrane signal receptor (PC00197)8.30%
 Scaffold/adaptor protein (PC00226)4.20%
 Defense/immunity protein (PC00090)4.20%
 Cytoskeletal protein (PC00085)4.20%
 Structural protein (PC00211)4.20%
 Extracellular matrix protein (PC00102)4.20%
 Translational protein (PC00263)4.20%
Downregulated glycoproteins
 Metabolite interconversion enzyme (PC00262)13.70%
 Nucleic acid metabolism protein (PC00171)12.40%
 Protein-modifying enzyme (PC00260)12.40%
 Gene-specific transcriptional regulator (PC00264)9.90%
 Transmembrane signal receptor (PC00197)9.30%
 Scaffold/adaptor protein (PC00226)6.80%
 Transporter (PC00227)6.20%
 Protein-binding activity modulator (PC00095)5.00%
 Translational protein (PC00263)5.00%
 Defense/immunity protein (PC00090)3.70%
 Intercellular signal molecule (PC00207)3.10%
 Cytoskeletal protein (PC00085)2.50%
 Chromatin/chromatin-binding or chromatin-regulatory protein (PC00077)2.50%
 Membrane traffic protein (PC00150)2.50%
 Cell adhesion molecule (PC00069)1.90%
 Structural protein (PC00211)1.20%
 Extracellular matrix protein (PC00102)0.60%
 Chaperone (PC00072)0.60%
 Cell junction protein (PC00070)0.60%