Research Article

Serum Glycoproteomics and Identification of Potential Mechanisms Underlying Alzheimer’s Disease

Table 6

Unique glycoproteins in the AD group classified by the molecular function, biological process, and pathways.

ClassificationPercentage (%)ClassificationPercentage (%)

Molecular functionPathways
Organic cyclic compound binding (GO:0097159)26.0Alzheimer disease-presenilin pathway (P00004)16.60%
Heterocyclic compound binding (GO:1901363)26.0Inflammation mediated by chemokine and cytokine signaling pathway (P00031)9.20%
Protein binding (GO:0005515)24.7Apoptosis signaling pathway (P00006)5.10%
Ion binding (GO:0043167)5.5Integrin signaling pathway (P00034)5.10%
Small molecule binding (GO:0036094)5.5Wnt signaling pathway (P00057)5.10%
Carbohydrate binding (GO:0030246)5.6p53 pathway (P00059)3.70%
Carbohydrate derivative binding (GO:0097367)4.1Metabotropic glutamate receptor group III pathway (P00039)2.60%
Protein-containing complex binding (GO:0044877)2.7Ionotropic glutamate receptor pathway (P00037)2.60%
Biological processGamma-aminobutyric acid synthesis (P04384)2.60%
Cellular process (GO:0009987)32.30%Dopamine receptor-mediated signaling pathway (P05912)2.60%
Metabolic process (GO:0008152)15.50%p53 pathway feedback loops 2 (P04398)2.60%
Biological regulation (GO:0065007)15.10%Endothelin signaling pathway (P00019)2.60%
Response to stimulus (GO:0050896)9.20%Parkinson disease (P00049)2.60%
Localization (GO:0051179)8.00%EGF receptor signaling pathway (P00018)2.60%
Signaling (GO:0023052)6.40%PDGF signaling pathway (P00047)2.60%
Developmental process (GO:0032502)4.80%Ras pathway (P04393)2.60%
Multicellular organismal process (GO:0032501)4.80%Notch signaling pathway (P00045)2.60%
Others4.0%Muscarinic acetylcholine receptor 2 and 4 signaling pathway (P00043)2.60%
Cadherin signaling pathway (P00012)2.60%
Metabotropic glutamate receptor group I pathway (P00041)2.60%
Carbohydrate derivative binding (GO:0097367)4.1Metabotropic glutamate receptor group II pathway (P00040)2.60%
CCKR signaling map (P06959)2.60%
Beta2 adrenergic receptor signaling pathway (P04378)2.60%
Formyltetrahydroformate biosynthesis (P02743)2.60%
Beta1 adrenergic receptor signaling pathway (P04377)2.60%
5HT1 type receptor-mediated signaling pathway (P04373)2.60%
Transcription regulation by bZIP transcription factor (P00055)2.60%
GABA-B receptor II signaling (P05731)2.60%
Enkephalin release (P05913)1.50%
B cell activation (P00010)1.00%