Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis

Table 2

Genotype frequency of MTHFR C677T gene polymorphisms in MCI patients and the control group.

Author (year)	Genotype										HWE
	MCI patients					Control
	C	T	CC	CT	TT	C	T	CC	CT	TT
Roussotte (2017) [36]	455	263	149	157	53	264	148	84	96	26
Luo (2015) [37]	175	83	62	51	16	190	72	67	56	8
Kaur (2018) [38]	451	75	194	63	6	444	108	179	86	11
El-Batch (2010) [39]	36	20	11	14	3	33	7	14	5	1
Zou (2016) [40]	181	67	61	59	4	173	75	62	49	13
Xing (2019) [41]	46	54	15	16	19	83	37	32	19	9
Wang (2019) [42]	216	114	82	52	31	165	59	68	29	15
Li (2017) [43]	54	76	17	20	28	77	49	28	21	14

MCI: mild cognitive impairment; HWE: Hardy–Weinberg Equilibrium; OR: odds ratio.