Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis
Table 3
Meta-analysis of the association between MTHFR C677T polymorphisms and MCI susceptibility and Egger’s test.
Comparison
Model
Pooled estimate value
Heterogeneity
for Egger’s test
OR
95% CI
T vs. C
8
Random
1.318
0.964-1.801
1.73
0.084
78.6%
≤0.001
0.066
CT+TT vs. CC
8
Random
1.296
0.925-1.817
1.51
0.132
68.4%
0.002
0.006
TT vs. CC+CT
8
Random
1.397
0.845-2.312
1.30
0.193
62.1%
0.010
0.859
CT vs. CC
8
Fixed
1.031
0.855-1.243
0.32
0.749
46.3%
0.071
0.005
TT vs. CC
8
Random
1.506
0.850-2.667
1.40
0.160
67.1%
0.003
0.859
: number of cases; OR: odds ratio; 95% CI: 95% confidence intervals; : Z test; : value; : test.
