Behavioural Neurology

Research Article

Upper and Lower Limb Motor Function Correlates with Ipsilesional Corticospinal Tract and Red Nucleus Structural Integrity in Chronic Stroke: A Cross-Sectional, ROI-Based MRI Study

Table 2

Multiple regression analyses of tract/region-specific FA and upper and lower limb motor performance.


Behavioral measure	Predictors		statistic	value for

BBT_Aff ()^a
Model 1	TSS, FA CST_ipsi	0.264	5.21	0.012	-0.258	0.335
Model 2	TSS, FA CST_ipsi, FA RN_ipsi	0.270	3.45	0.030	-0.230	0.344	0.076
Grip_Aff ()^a
Model 1	FA CST_ipsi	0.373	22.03	≤0.001†		0.611
Model 2	FA CST_ipsi, FA RN_ipsi	0.374	10.74	≤0.001†		0.597	0.027
Arm MI_Aff ()^b
Model 1	FA CST_ipsi	0.315	10.13	0.004†		-0.561
Model 2	FA CST_ipsi, FA RN_ipsi	0.337	5.34	0.013		-0.472	-0.173
Leg MI_Aff ()
Model 1	FA CST_ipsi	0.186	5.72	0.025		0.432
Model 2	FA CST_ipsi, FA RN_ipsi	0.241	3.82	0.036		0.282	0.278
Gait speed ()^c
Model 1	TSS, FA RN_ipsi	0.237	5.82	0.021	-0.239	—	0.365

Abbreviations: BBT_Aff: Box and Block Test (affected limb); Grip_Aff: grip strength (affected limb); Arm MI_Aff: Arm Motricity Index score (affected limb); Leg MI_Aff: Leg Motricity Index score (affected limb); TSS: time since stroke; FA: fractional anisotropy; CST: corticospinal tract; RN: red nucleus. †Significant at corrected . ; ; ª2 outliers removed; ^bArm MI_Aff behavioral scores reflect and square root transformed; ^c1 outlier removed.