Endogenous Estrogen Influences Predator Odor-Induced Impairment of Cognitive and Social Behaviors in Aromatase Gene Deficiency Mice

Figure 2

TMT-induced acute and chronic changes in the novel object recognition test in WT mice and Ar+/- mice. WT mice showed shorter time spent in exploring the novel object (a) and lower discrimination index (b) 24 h after TMT exposure, particularly in females, while the Ar+/- mice showed genotype-specific impairment of preference to novel object 24 h after TMT exposure (c, d). One month after TMT exposure, there were no significant differences between the DEP group and TMT group in the exploration time and discrimination index in the WT mice (e, f) and Ar+/- mice (g, h), respectively. Data are shown as . , , and .