Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy

Figure 16

Photomicrographs of the hippocampus of albino rat group V (PLC/L) reveal (a) CA1, (b) CA3, and (c) DG. CA areas are formed of three layers. Most of pyramidal cells are seen with basophilic cytoplasm (↑) and vesicular nuclei. Few dark stained neurons with perineural space are seen in the pyramidal layer of CA3 (↑). Dentate gyrus is formed of the molecular (M) layer, granule cell layer (G), and polymorphic layers (P2). Most of granular cells are seen with basophilic cytoplasm (↑) and vesicular nuclei. Inset: higher magnification of the granular cells. Scale bar: 50 μm, group V (PLC/L), H&E ×20 and inset ×40.

(a)

(b)

(c)