Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy

Figure 4

A photomicrograph of the hippocampus form albino rat group I (negative control group). Images show the (a) CA1 and (b) CA3 areas of hippocampus proper and (c) dentate gyrus. CA areas are formed of three layers: molecular layer (M), pyramidal (Pr), and polymorphic (P1) layers. Molecular layer is a relatively cell-sparse area. Pyramidal cells are arranged in the compact layer with little neuropil between the cells. They are seen with basophilic cytoplasm (↑) and vesicular nuclei. The granule cell layer (G) of the dentate gyrus formed mainly of uniformly sized closely packed granule cells with rounded cell bodies and vesicular nuclei. Notice glial cells (yellow arrow) and deeply stained interneurons (curved black arrow) in molecular and polymorphic layers (P1 and P2). Scale bar: 50 μm, group I, H&E ×20.

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