Dextromethorphan Dampens Neonatal Astrocyte Activation and Endoplasmic Reticulum Stress Induced by Prenatal Exposure to Buprenorphine

<div>Prenatal exposure to buprenorphine escalates astrocyte activation in the hippocampus of the neonates concurrent with increased GPR37 immunoreactivity. Prenatal treatments: buprenorphine (Bu), dextromethorphan (Dm), coadministration of buprenorphine with dextromethorphan (Bu+Dm), or vehicle controls (Con). (a) Confocal images (20x objective, left panel) for GPR37 (red) and GFAP (green) immunoreactivity in the hippocampus of neonates, with images at a higher magnification (63x objective) for GPR37 punctate staining (red) in the CA1 (right panel). (b) Western blot analysis of hippocampal GFAP expression levels with quantification. DAPI (blue) staining identifies nuclei. 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Behavioural Neurology

fig1

Figure 1

Figure 1: Dextromethorphan Dampens Neonatal Astrocyte Activation and Endoplasmic Reticulum Stress Induced by Prenatal Exposure to Buprenorphine 