Dextromethorphan Dampens Neonatal Astrocyte Activation and Endoplasmic Reticulum Stress Induced by Prenatal Exposure to Buprenorphine

Figure 2

ER and oxidative stresses are induced by prenatal exposure to buprenorphine in the hippocampus of the neonates. (a) Western blot analysis of the expression levels of hippocampal GPR37 monomer and high molecular weight (M.W.) aggregates with quantification. (b) Quantification of Western blot analysis for the expression levels of GPR78, caspase-12, procaspase-3, caspase-3, CHOP, iNOS, and COX-2 in the hippocampus of the neonates with prenatal exposure to Bu, Dm, Bu+Dm, or Con. Data are % of control; vs. Con and vs. Con and ^## vs. Bu and ^### vs. Bu.

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