Synergistic Effects of Aldehyde Dehydrogenase 2 Polymorphisms and Alcohol Consumption on Cognitive Impairment after Ischemic Stroke in Han Chinese

Table 5

Adjusted odds ratios (95% confidence intervals)^a for the separate effects of ALDH2 polymorphism and alcohol consumption on cognitive impairment in ischemic stroke patients.

	Method 1	Method 2
ALDH2 genotypes
	Ref	Ref
	3.29 (1.03-10.50)	2.65 (1.19-5.92)
Alcohol consumption
Nondrinkers	Ref	Ref
Light drinkers	0.59 (0.16-0.89)^#	0.68 (0.33-0.89)^#
Moderate drinkers	0.77 (0.21-1.06)	1.08 (0.83-2.19)
Excessive drinkers	1.22 (1.16-1.49)^#	1.78 (1.03-2.15)^#

^aModels were adjusted for age, gender, and education. vs. ALDH2 wild-type genotype group (). ^# vs. nondrinkers.