|
| Reference | Groups | N | Mean age (years) + SD | Disease duration, years | UPDRS III | Hoehn-Yahr |
|
| Abbes et al. (2018) [7] | Baseline
Follow-up | 102
69 |
|
|
| –
– |
|
| Alvarado-Bolaños et al. (2015) [8] | No NPS | 76 | | | (range 2–53) | 30.3% (stage I); 68.4% (stages II–III); 1.3% (stages IV–V) |
| With NPS | 416 | | | (range 1–107) | 11.3% (stage I); 76.4% (stages II–III); 12.3% (stages IV–V) |
|
| Belarbi et al. (2010) [9] | PD patients with LRRK2 G2019S mutation | 23 | | | — | — |
| PD patients without LRRK2 G2019S mutation | 48 | | | — | — |
|
| Cuciureanu et al. (2019) [10] | PD patients | 112 | 66.0 | Mean age of onset 61 years old | — | — |
|
| Guo et al. (2015) [11] | EOPD
LOPD | 97
251 |
|
|
|
|
|
| Hassin-Baer et al. (2011) [12] | PD patients with CRP ≤3 | 40 | | | | Stage II
(stages 2–3) |
| PD patients with CRP >3 | 33 | | | | Stage II
(stages 2–2.5) |
|
| Lamberti et al. (2016) [13] | General PD patients
Surgical PD patients | 260
234 |
|
|
|
|
|
| Lang et al. (2020) [14] | PD patients | 74 | | | | Stage I, II, and III |
|
| Lewis et al. (2012) [15] | PD patients
Healthy controls | 20
20 |
|
– |
– |
– |
|
| Martinez-Martin et al. (2015) [16] | Dementia PD patients
No dementia PD patients | 488
94 | Full sample: | | –
– | Full sample ():
22.8% (stage I); 46.0% (stage II); 17.8% (stage III); 10.6% (stage IV); 2.7% (stage V) |
|
| Merino-Lopez (2016) [17] | PD patients: | | | | | |
1st evaluation
2nd evaluation | 92
29 |
|
|
|
|
|
| Morley et al. (2011) [18] | UPSIT bottom median score
UPSIT top median score | 123
125 |
|
|
|
|
|
| O’Callaghan et al. (2014) [19] | No NPS PD patients
NPS PD patients
Healthy controls | 25
25
30 |
|
– |
– |
– |
|
| Ojagbemi et al. (2013) [20] | PD patients
Hypertension patients | 50
50 |
|
– |
– | –
– |
|
| Orfei et al. (2018) [21] | Mild dementia PD patients | 47 | | | | |
| Multidomain cognitive impairment PD patients | 136 | | | | |
| Single domain cognitive impairment PD patients | 5 | | | | |
| No cognitive impairment PD patients | 197 | | | | |
|
| Oruç et al. (2017) [22] | PD patients | 46 | | | — | 30.4% (≤2, mild PD); 69.6% (>2, severe PD) |
| Healthy controls | 46 | | — | — | — |
|
| Pavlova et al. (2014) [23] | Late onset PD e3/e4
Late onset PD e3/e3
Healthy controls | 16
30
20 |
|
– |
– | –
–
– |
|
| Pérez-Pérez et al. (2015) [24] | PD patients on pramipexole
PD patients on ropinirole
PD patients on levodopa | 250
150
115 |
|
| –
–
– |
|
|
| Petrovic et al. (2016) [25] | PD patients | 360 | | | | 54.2% (mild PD, stage I–II); 36.4% (moderate PD, stage III); 9.4% (severe PD, stage IV–V) |
|
| Pirogovsky-Turk et al. (2017) [26] | PD patients | 68 | | | | 1.5% (stage 0); 19.1% (stage I); 1.5% (stage 1.5); 60.3% (stage II); 4.4% (stage 2.5); 11.7% (stage III); 1.5% (stage IV) |
| Healthy controls | 30 | | — | — | — |
|
| Pontieri et al. (2015) [27] | No ICD
Pathological gambling
Other variants of ICD | 98
21
36 |
|
|
|
|
|
| Radziunas et al. (2020) [28] | Baseline: | | | | | |
PD patients
Healthy controls | 22
18 |
| –
– |
– | –
– |
| Post-operative: | | | | | |
| PD patients with no NPS | 15 | | | (ON state); (OFF state) | – |
| PD patients with NPS | 7 | | | (ON state); (OFF state) | — |
|
| Rai et al. (2015) [29] | Young onset PD
Late onset PD | 26
100 |
|
|
|
|
|
| Riedel et al. (2010) [30] | Neither depression nor dementia
Depression
Dementia
Both | 875
167
229
178 |
|
5 | –
–
–
– | Full sample ():
44.2% (stages I–II); 38.7% (stage III); 17.1% (stages IV–V) |
|
| Santangelo et al. (2018) [31] | PD patients
PSP
Multiple system atrophy | 55
42
44 |
|
|
–
– | –
–
– |
|
| Stephenson et al. (2010) [32] | PD patients | 100 | | | Evaluated but not informed | 44% (stage 1.5); 46% (stage 2); 1% (stage 2.5); 3% (stage 3) |
|
| Solla et al. (2011) [33] | PD no motor complications
PD + motor complications
PD + dyskinesias
PD + motor fluctuations | 87
262
99
254 |
|
|
|
|
|
| Swan et al. (2016) [34] | Idiopathic PD patients
GBA-associated PD | 55
31 |
|
|
|
|
|
| Weintraub et al. (2010) [35] | PD on atomoxetine
PD on placebo | 28
27 |
|
|
| –
– |
|
| Xing et al. (2016) [36] | PD + dementia
PD no dementia
Healthy controls | 38
40
40 |
|
– |
– | –
–
– |
|
