The Improvement of Sepsis-Associated Encephalopathy by P2X7R Inhibitor through Inhibiting the Omi/HtrA2 Apoptotic Signaling Pathway

Figure 1

Treatment with P2X7R inhibitor A-438079 improved LPS-induced cognitive dysfunction and SAE in mice. (a) A-438079 treatment rescued LPS-induced weight loss. (b) Treatment of A-438079 significantly alleviated the reduced survival rate in mice caused by LPS. (c) The distance traveled by each group to reach the platform during the training period. Mice traveling distance was significantly reduced after treatment with A-438079 compared with the LPS and LPS+ DMSO groups. (d) Mice in LPS groups and groups expressed a signally longer escape latency than the control group. Treatment with A-438079 significantly reduced the extension of the escape latency after LPS treatment, . All data are expressed as . vs. control, ^# vs. LPS group, and ^@@ vs. group. (e) The number of times the mice crossed the platform was significantly reduced in the LPS group compared with the control group but increased after treatment with A-438079 compared with the LPS group, moreover, the number of mice crossing the platform in the group was significantly decreased compared with the group; . All data are expressed as . vs. control, ^## vs. LPS group, and ^@@ vs. group.

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