The Improvement of Sepsis-Associated Encephalopathy by P2X7R Inhibitor through Inhibiting the Omi/HtrA2 Apoptotic Signaling Pathway

Figure 4

A-438079 treatment decreased LPS-induced transposition of Omi/HtrA2 from mitochondria to cytoplasm and reversed the decrease in XIAP expression. (a) and (c) A-438079 reduced LPS-induced increase of Omi/HtrA2 in the cytoplasm of HBMECs in vitro. All data are expressed as . compared with control, ^# compared with LPS, and ^@ compared with . (b) and (d) Under the effect of LPS, the mitochondrial Omi/HtrA2 of HBMECs in vitro was significantly decreased compared with the control group, and this reduction could be inhibited by A-438079. All data are expressed as . compared with control, ^# compared with LPS, and ^@ compared with . (e) and (f) Western Blot showed that LPS treatment could inhibit the expression of the apoptosis inhibitor protein XIAP and could be reversed by A-438079. All data are expressed as . compared with control, ^# compared with LPS, and ^@ compared with .

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