The Improvement of Sepsis-Associated Encephalopathy by P2X7R Inhibitor through Inhibiting the Omi/HtrA2 Apoptotic Signaling Pathway

Figure 5

A-438079 inhibited Cleaved caspase-9 and Cleaved caspase-3 expression upregulation induced by LPS stimulation and LPS-induced apoptosis of brain cells in mice. (a)–(d) LPS-induced the increasing of Cleaved caspase-9 and Cleaved caspase-3 expression was inhibited by A-438079. All data are expressed as . compared with control, ^# compared with LPS, ^@@ compared with . (e) and (f) TUNEL fluorescence staining shows apoptosis of cells in the brain of mice. . All data are expressed as . compared with control, ^# compared with LPS, and ^@@ compared with .

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