Mitigated Oxidative Stress and Cognitive Impairments in Transient Global Ischemia using Niosomal Selegiline-NBP delivery

Figure 12

H&E staining images in experimental groups. The effects of different doses of selegiline on neural cell death of hippocampus. Cell death was evaluated via hematoxylin-eosin (H&E) staining at 400x magnification. (a):control group; (b) stroke or untreated transient global ischemia rats; (c) nonischemic rats received only noisome+NBP; (d) nonischemic rats received 1 mg/kg of selegiline in niosomal selegiline-NBP structure; (e) stroke rats received selegiline (0.25 mg/kg) in niosomal selegiline-NBP structure; (f) stroke rats received selegiline (0.5 mg/kg) in niosomal selegiline-NBP structure; (g) stroke rats received selegiline (1 mg/kg) in niosomal selegiline-NBP structure. Arrows indicate dead cells.

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