Research Article
Mitigated Oxidative Stress and Cognitive Impairments in Transient Global Ischemia using Niosomal Selegiline-NBP delivery
Table 1
Applied statistical models to release data of selegiline.
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a and are the remained amounts of the decoy ODN in the nanocarrier system in the time zero and , respectively; is the zero-order release constant. b is the first-order release constant. c is the Higuchi release constant. e is the release constant in Hixson–Crowell model. j is the scale parameter which defines the time scale of the process; is the shape parameter which characterizes the curve as either exponential (; case 1), sigmoid, S-shaped, with upward curvature followed by a turning point (; case 2), or parabolic, with a higher initial slope and after that consistent with the exponential (; case 3); is the location parameter which represents the lag time before the onset of the dissolution or release process and in most cases will be near zero. m is the scale factor in the Gompertz model; is the shape factor in the Gompertz model. |