Review Article
Shared Etiology in Autism Spectrum Disorder and Epilepsy with Functional Disability
Table 1
Correlating genetic disorder in both epilepsy and ASD.
| | Genetic syndromes | Coexistence ( value) | Proportion of epilepsy % () | value | Proportion of ASD % () | value |
| | Tuberous sclerosis complex | | 10.8% () [73]
70-80% () [74] | ()
() | 25-50% () [75] | () | | Down syndrome | (), () | 8% ()
1%–13% () [73] | () () | 5.8% [76]
3.1% () [72]
18.2% () [77] | () () | | Dravet syndrome | | 100%()
100% () [78] | ()
() | 61.5% ()
24.3% () [79] | () () | | Fragile X syndrome | 28.1% () () | 11.8%–18% () [80] | () | 30% [81]
21% () | () | | Rett syndrome | | 61% () [82] | () | Transitory autism features () [83] | () | | Pitt–Hopkins syndrome | | 50%() [84] | () | 100% () [85] | () | | Hypomelanosis of Ito syndrome | () () [86] | 37%–53% [87]
11.5%–50%()
49% () [88] | ()
() | 64% () [89]
10% of patients with ID () [90] | ()
() | | Smith–Lemli–Opitz syndrome | () () | () [91] | () | 53% () [92] | () | | Sotos syndrome | | Rare () [93] | () | 41% () [94] | () | | Angelman syndrome | () (p <0.05) [95] | 100% ()
[96]
85% () [97] | ()
() | 42% ()
[98]
1.9% () [99] | ()
() |
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