Comorbid Neurodegeneration in Primary Progressive Aphasia: Clinicopathological Correlations in a Single-Center Study

Figure 1

Overview of typical MRI findings in our cases. Asymmetrical atrophy of the opercular and medial temporal lobe was seen in nfvPPA patients ((a) cases 1, 2, 3, and 6; in case 4, temporal atrophy predominated on the right side) and in case 9 with lvPPA. Early left-side anterotemporal atrophy was detected in svPPA patients ((b) cases 7 and 8). In contrast, parietal atrophy of various degrees was rather symmetric in our cases (c), except in case 8. Leukoaraiosis ranged from very mild ((d) Fazekas grade 1) to severe ((e) Fazekas grade 3). GGT comorbidity was associated with atrophy of the mesencephalon (“hummingbird sign”) and with callosal atrophy ((f) cases 3, 6, and 7).

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