Metformin Alleviates Autistic-Like Behaviors Elicited by High-Fat Diet Consumption and Modulates the Crosstalk Between Serotonin and Gut Microbiota in Mice

Figure 1

Effect of HFD and metformin treatment on body weight, fasting blood glucose levels, and glucose tolerance. (a) Time curve of body weight gain. (b) Time curve of fasting blood glucose levels. (c) OGTT response in HFD-fed mice after metformin administration (). Values are presented as . , , and superscripts indicate significant differences between the ND vs. HFD + Veh groups; ^#, ^##, and ^### superscripts indicate significant differences between the HFD + vehicle vs. HFD + Met groups. OGTT: oral glucose tolerance test; ND: normal diet; HFD: high-fat diet; Met: metformin.

(a)

(b)

(c)